Analysis of Etiology and Drug Resistance of Invasive Fungal Infections in Intensive Care Unit

  • Lan Ding
Keywords: Intensive Care, Invasive Fungi, Fungal Infection, Drug Resistance


In recent years, under the influence of various factors, the probability of invasive fungal infection in hospitals is
increasing, especially in patients in intensive care units, whose immune function is relatively low, and they are
more prone to invasive fungal infection. In general, the characteristics of invasive fungal infections vary greatly
depending on the patient's condition. In the intensive care unit, most of the patients have a variety of basic
diseases, the rate of fungal infection is much higher than that of the general ward, and the mortality rate is
between 38% and 68%. Therefore, it is of great significance to study the etiology and drug resistance of invasive
fungal infections. The purpose of this study was to study the etiology and drug resistance of invasive fungal
infections in intensive care units to find an effective treatment for invasive fungal infections and to minimize the
risk of invasive fungal infections. Firstly, the background of the study is described and the actual situation of
invasive fungal infection in China is analyzed. Then the concept of invasive fungal infection is discussed in
detail, and the method of data analysis is used to analyze and introduce invasive fungal infection at home and
abroad. In addition, five criteria of fungal infection have been established from five perspectives. The most
important thing is that this paper analyzes the risk factors affecting invasive fungal infection from four
perspectives, namely host, hospital environment, human immunity and iatrogenicity. The experimental results
show that the proportion of invasive fungal infections in China has increased in recent years, from 23.47% in
2013 to 47.32% in 2019, and from 9.26% to 15.32% in icu. Among the 513 patients involved in the
investigation, common fungal infection types candida albicans accounted for 48.1%, candida smooth accounted
for 29.6%, candida tropical accounted for 14.8%, candida near-smooth accounted for 3.7%, candida clovis
accounted for 3.7%. In addition, the sites of invasive fungal infection mainly included the urinary system,
respiratory tract and blood, with the incidence rates of 63.0%, 25.9% and 11.1% respectively. The resistance of
candida albicans and candida albicans to fluconazole was 15.38% and 57.1% respectively, and the average
resistance of the five strains to fluconazole was 37%.