The Efficacy of Cat Score, Serum Il-6, Il-18 and CC16 on the Prognosis of Moderate and Severe Copd Patients
Objective: Our objective is to analyze the efficacy of chronic obstructive pulmonary disease assessment test (CAT) score, serum interleukin-6 (IL-6), IL-18 and human Clara cell secretory 16-kD protein (CC16) on the prognosis of moderate and severe chronic obstructive pulmonary disease (COPD) patients, which provides a reference to predict the prognosis of COPD patients. Methods 182 moderate and severe COPD patients admitted in our hospital during April, 2012-April, 2015 were included in the observation group, and 150 healthy people were included in the control group for prospective analysis. Serum IL-6, IL-18 and CC16 were detected and the differences were analyzed. Pearson’s correlation analysis was used to analyze the correlation of CAT score, serum IL-6, IL-18 and CC16 with pulmonary function, 2-year acute exacerbation times and 6-minute walk distance in moderate and severe COPD patients (P＜0.05). Results The serum IL-6 and IL-18 in the observation group were higher than the control group, and CC16 was lower than the control group, which were statistically significant (P＜0.05). In the observation group, CAT score was normal in 104 patients and abnormal in 78 patients, the second day serum IL-6, IL-16 and CC16 were statistically different between patients with normal and abnormal CAT scores (P＜0.05). Pearson’s correlation analysis showed that CAT score, IL-6 and IL-18 were positively correlated with the 2-year acute exacerbation times, and negatively correlated with FEV1, FEV1/FVC and 6-minute walk distance. CC16 was negatively correlated with the 2-year acute exacerbation times, and positively correlated with FEV1, FEV1/FVC and 6-minute walk distance (P＜0.05). Conclusion CAT scores, serum IL-6, IL-18 and CC16 are closely correlated to the prognosis of moderate and severe COPD patients. Evaluation of the patient prognosis and actively intervention based on this can improve the life quality of patients.