Observe Efficacy of Lansoprazole or Omeprazole Respectively Combined With Somatostatin in Treatment of Severe Pancreatitis

  • Wei Jia, Bixia Weng, Hongli Yu et al.


To investigate the efficacy of lansoprazole or omeprazole respectively combined with somatostatin in treatment of severe pancreatitis. Choose our hospital treatment of 148 patients from June 2014 to December 2015 in our department with severe pancreatitis were randomly divided into observation group (lansoprazole combined somatostatin treatment 78 cases) and control group(omeprazole combined somatostatin treatment 70 cases ).The clinical efficacy, recovery time and laboratory index were compared between the two groups. There was no significant difference in curative effect between the two groups (P >0. 05) .In observation group, Hospitalization time, the relief time and return to normal time of abdominal pain and distension were significantly lower than those in the control group, The difference was statistically significant (P<0.05).However, the recovery time of blood and urine amylase was no significant difference between the control group and the control group (P>0.05). Lansoprazole or omeprazole combined with somatostatin in the treatment of severe acute pancreatitis were achieved satisfactory curative effect, but in the lansoprazole group have significant effect to abdominal pain relief time and hospitalization time, provides a variety of options for severe acute pancreatitis in the antisecretory drugs selection.